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The integration of more clinically relevant models and study designs will strengthen the translational impact of basic research and guide the development of effective ovarian protective strategies for women undergoing CP chemotherapy

In the absence of an appropriate compensation by the endogenous antioxidant defense network, increased oxidative stress leads to the activation of stress-sensitive intracellular signaling pathways and the formation of gene products that cause cellular damage and contribute to the late complications of diabetes [3,4]

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however, there are no human trials yet to show vision benefits